James Gleason was born in New York City to William Gleason and Mina Crolius, who were both in the theatre. He was married to Lucile Gleason (born Lucile Webster), and had a son, Russell Gleason. As a young man James fought in the Spanish-American War. After the war he joined the stock company at the Liberty Theater in Oakland, California, which his parents were running. James and his wife then moved to Portland, Oregon, where they played in stock at the Baker Theater. For several years afterward they toured in road shows until James enlisted in the army during World War I. When he returned he appeared on the stage in "The Five Million." He then turned to writing, including "Is Zat So", which he produced for the NY stage. He also wrote and acted in "The Fall Guy" and "The Shannons on Broadway." Next he wrote The Broadway Melody (1929) for MGM. He collaborated, in 1930, on The Swellhead (1930), Dumbbells in Ermine (1930), What a Widow! (1930), Rain or Shine (1930) and His First Command (1929). He and his wife were then contracted to Pathe, Lucille to act, and James (or Jimmie as he was known) as a writer. Probably his most famous acting role was as Max Corkle, the manager of Joe Pendleton who was wrongly plucked from this life into the next, in the hit fantasy Here Comes Mr. Jordan (1941).
| Movie | Rules Don't Apply | Doctor Crone | 2016-11-23 |
| Movie | Awaken | Willy | 2013-04-09 |
| Movie | Stealing Roses | Marco | 2012-06-01 |
| Movie | American Dreamz | Journalist | 2006-03-04 |
| Movie | S1m0ne | Reporter | 2002-08-23 |
| Movie | Shadow of the Blair Witch | Jeff Schoene | 2000-10-22 |
| Movie | Why Do Fools Fall In Love | Stage Manager | 1998-08-28 |
| Movie | Mother | Waiter | 1996-12-25 |
| Movie | Sawbones | Coroner | 1995-07-25 |
| Movie | Revenge of the Nerds IV: Nerds In Love | 1994-05-09 | |
| Movie | Bloodlines: Murder in the Family | Controller | 1993-03-01 |
| Movie | Jason Goes to Hell: The Final Friday | Agent Abernathy | 1993-08-13 |
| Movie | Star | The Director | 1993-09-20 |
| Movie | For Richer, for Poorer | Salesman | 1992-01-01 |
| Movie | Boris and Natasha | Taxi Driver | 1992-04-17 |
| Movie | My Demon Lover | Alert Cop | 1987-04-24 |
| Movie | Hollywood My Home Town | Self (archive footage) | 1965-12-31 |
| Movie | Man or Gun | Sheriff Jim Jackson | 1958-05-30 |
| Movie | The Female Animal | Tom Maloney | 1958-01-22 |
| Movie | Rock-a-Bye Baby | Doc Simpkins | 1958-07-23 |
| Movie | Once Upon a Horse... | Postmaster | 1958-09-01 |
| Movie | The Last Hurrah | Cuke Gillen | 1958-12-31 |
| Movie | Money, Women and Guns | Henry Devers | 1958-10-01 |
| Movie | Spring Reunion | Collie | 1957-03-01 |
| Movie | Man in the Shadow | Hank James | 1957-12-12 |
| Series | Leave It to Beaver | Unknown | 1957-10-04 |
| Movie | Star in the Dust | Orval Jones | 1956-06-13 |
| Movie | The Night of the Hunter | Uncle Birdie Steptoe | 1955-07-27 |
| Movie | The Girl Rush | Ether Ferguson | 1955-09-16 |
| Movie | Screen Directors Playhouse: Rookie of the Year | Ed Shafer | 1955-12-07 |
| Series | Alfred Hitchcock Presents | Unknown | 1955-10-02 |
| Movie | Suddenly | Peter 'Pop' Benson | 1954-09-17 |
| Movie | Forever Female | Eddie Woods | 1953-11-28 |
| Movie | We're Not Married! | Duffy | 1952-07-11 |
| Movie | The Story of Will Rogers | Bert Lynn | 1952-07-17 |
| Movie | What Price Glory | General Cokely | 1952-08-22 |
| Series | Cavalcade of America | Unknown | 1952-10-01 |
| Movie | Come Fill the Cup | Charley Dolan | 1951-10-24 |
| Series | Racket Squad | Unknown | 1951-06-07 |
| Movie | I'll See You in My Dreams | Fred Townsend | 1951-12-06 |
| Movie | Key to the City | Sergeant Hogan | 1950-02-02 |
| Movie | The Yellow Cab Man | Mickey Corkins | 1950-03-25 |
| Movie | Riding High | Racing Secretary | 1950-04-12 |
| Movie | Joe Palooka in the Squared Circle | Knobby Walsh | 1950-11-04 |
| Movie | The Jackpot | Harry Summers | 1950-11-01 |
| Series | The Colgate Comedy Hour | Unknown | 1950-09-10 |
| Movie | A Guy Named Joe | “Nails” Kilpatrick | 1949-01-08 |
| Movie | Bad Boy | Chief | 1949-02-22 |
| Movie | The Life of Riley | Gillis | 1949-04-16 |
| Movie | Take One False Step | Captain Gledhill | 1949-08-14 |
| Movie | Smart Woman | Sam Corkle | 1948-04-30 |
| Movie | The Dude Goes West | Sam Briggs | 1948-05-30 |
| Movie | When My Baby Smiles at Me | Lefty Moore | 1948-11-10 |
| Movie | The Return of October | Uncle Willie Ramsey | 1948-10-26 |
| Movie | Down to Earth | Max Corkle | 1947-08-21 |
| Movie | The Homestretch | Doc Kilborne | 1947-05-04 |
| Movie | The Bishop's Wife | Sylvester | 1947-12-25 |
| Movie | Tycoon | Pop Mathews | 1947-12-27 |
| Movie | The Hoodlum Saint | Snarp | 1946-04-04 |
| Movie | The Well Groomed Bride | Captain Hornby | 1946-05-17 |
| Movie | Home Sweet Homicide | Sgt. O'Hare | 1946-10-02 |
| Movie | Lady Luck | Sacramento Sam | 1946-10-30 |
| Movie | A Tree Grows in Brooklyn | McGarrity | 1945-02-28 |
| Movie | This Man's Navy | Jimmy Shannon | 1945-01-04 |
| Movie | The Clock | Al Henry | 1945-05-25 |
| Movie | Captain Eddie | Tom Clark | 1945-06-18 |
| Movie | Arsenic and Old Lace | Lt. Rooney | 1944-09-01 |
| Movie | Once Upon a Time | Moke McGillicuddy | 1944-06-29 |
| Movie | The Keys of the Kingdom | Rev. Dr. Wilbur Fiske | 1944-12-15 |
| Movie | Crash Dive | Chief Mike 'Mac' McDonnell | 1943-04-22 |
| Movie | A Date with the Falcon | Inspector Michael 'Mike' O'Hara | 1942-01-16 |
| Movie | My Gal Sal | Pat Hawley | 1942-04-30 |
| Movie | Hay Foot | Colonel J. A. Barkley | 1942-01-02 |
| Movie | Tales of Manhattan | Joe - Mission Aid Society | 1942-08-05 |
| Movie | Manila Calling | Tim O'Rourke | 1942-10-16 |
| Movie | The Falcon Takes Over | Inspector Mike O'Hara | 1942-05-29 |
| Movie | Footlight Serenade | Bruce McKay | 1942-08-01 |
| Movie | Affectionately Yours | 'Chet' Phillips | 1941-05-10 |
| Movie | Here Comes Mr. Jordan | Max Corkle | 1941-08-07 |
| Movie | Meet John Doe | Henry Connell | 1941-03-14 |
| Movie | Tanks a Million | Col. 'Spitfire' Barkley | 1941-09-12 |
| Movie | Babes on Broadway | Thornton Reed | 1941-12-31 |
| Movie | Breakdowns of 1941 | Self (archive footage) (uncredited) | 1941-11-14 |
| Movie | Nine Lives Are Not Enough | Sergeant Daniels | 1941-09-20 |
| Movie | Grandpa Goes To Town | Joe Higgins | 1940-04-13 |
| Movie | My Wife's Relatives | Joe Higgins | 1939-05-20 |
| Movie | Should Husbands Work? | Joe Higgins | 1939-07-26 |
| Movie | Money To Burn | Joe Higgins | 1939-12-31 |
| Movie | On Your Toes | Phil Dolan Sr. | 1939-10-14 |
| Movie | Screen Snapshots Series 17, No. 6 | Self | 1938-02-04 |
| Movie | Army Girl | Hennessy | 1938-08-11 |
| Movie | The Higgins Family | Joe Higgins | 1938-03-28 |
| Movie | Forty Naughty Girls | Police Insp. Oscar Piper | 1937-09-24 |
| Movie | Cinema Circus | Himself | 1937-01-27 |
| Movie | Manhattan Merry-Go-Round | Danny The Duck | 1937-11-26 |
| Movie | Yours for the Asking | Saratoga | 1936-07-23 |
| Movie | Murder on a Bridle Path | Police Insp. Oscar Piper | 1936-04-17 |
| Movie | The Ex-Mrs. Bradford | Inspector Corrigan | 1936-04-24 |
| Movie | Don't Turn 'em Loose | Detective Daniels | 1936-09-18 |
| Movie | The Big Game | George Scott | 1936-10-09 |
| Movie | The Plot Thickens | Police Insp. Oscar Piper | 1936-12-11 |
| Movie | Murder on a Honeymoon | Police Insp. Oscar Piper | 1935-02-22 |
| Movie | West Point of the Air | Joe 'Bags' | 1935-03-23 |
| Movie | Hollywood Hobbies | Himself | 1935-07-05 |
| Movie | We're Only Human | Detective Danny Walsh | 1935-12-27 |
| Movie | Hot Tip | Jimmy McGill | 1935-08-20 |
| Movie | The Meanest Gal in Town | Duke Slater | 1934-01-12 |
| Movie | Search for Beauty | Dan Healy | 1934-02-02 |
| Movie | Change of Heart | Hot Dog Vendor (uncredited) | 1934-05-18 |
| Movie | Murder on the Blackboard | Police Insp. Oscar Piper | 1934-06-15 |
| Movie | Clear All Wires! | Lefty Williams | 1933-02-24 |
| Movie | Hoopla | Jerry | 1933-11-30 |
| Movie | High Hats and Low Brows | Danny Ruff | 1932-07-10 |
| Movie | Fast Companions | Silk Henley | 1932-06-22 |
| Movie | Blondie of the Follies | Pa McClune | 1932-09-01 |
| Movie | Lady and Gent | Pin Streaver | 1932-07-10 |
| Movie | The Crooked Circle | Arthur Crimmer | 1932-09-25 |
| Movie | Yoo-Hoo | Jimmy Gleason | 1932-10-04 |
| Movie | The Penguin Pool Murder | Police Insp. Oscar Piper | 1932-12-09 |
| Movie | The Devil Is Driving | 'Beef' Evans | 1932-12-09 |
| Movie | Beyond Victory | Jim Mobley | 1931-04-03 |
| Movie | A Free Soul | Eddie | 1931-06-02 |
| Movie | It's a Wise Child | Cool Kelly | 1931-04-10 |
| Movie | Sweepstakes | Sleepy Jones | 1931-07-10 |
| Movie | Suicide Fleet | Skeets | 1931-11-20 |
| Movie | The Big Gamble | Fred 'Squint' Dugan | 1931-09-04 |
| Movie | Puttin' on the Ritz | James 'Jimmy' Tierney | 1930-02-19 |
| Movie | Dumb-bells in Ermine | Mike | 1930-05-10 |
| Movie | The Matrimonial Bed | Gustave Corton | 1930-08-01 |
| Movie | Her Man | Steve | 1930-09-21 |
| Movie | The Broadway Melody | Music Publisher (uncredited) | 1929-02-08 |
| Movie | Oh, Yeah! | Dusty | 1929-10-19 |
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